Absorption of Some Glycol Ethers Through Human Skin in Vitro by Paul H. Dugard,* Michael Walker,* Susan J. Mawdsley' and Robert C. Scott* Tb assist evaluation of the hazards of skin contact with selected undiluted glycol ethers, their absorption across isolated human abdominal epidermis was measured in vitro. Propylene glycol skin sensitization occurred in patients sensitive to a number of other concomitant positive allergens, most common of which were: Myroxylon pereirae resin, benzalkonium chloride, carba mix, potassium dichromate, neomycin sulfate; for positive propylene glycol reactions, the overall median of 5 and mean of 5.6 concomitant positive allergens was reported. ETHYLENE GLYCOL N-BUTYL ETHER may react with bases, aluminum and oxidizing materials. Local effects on skin and mucous membranes. Toxicol Appl Pharmacol. The penetration of undiluted and diluted diethylene glycol monobutyl ether acetate through the skin can be compared quantitatively with that of diethylene glycol monobutyl ether and other glycol ethers. Marek EM, Koslitz S, Weiss T, Fartasch M, Schlüter G, Käfferlein HU, Brüning T. Arch Toxicol. Haz-Map®. Transcutol increases particle size and reduce diclofenac nanosuspensions solubility. Skin permeation was calculated using the Franz cell method with human skin. The Polypropylene Glycol (PPG) Stearyl Ethers are polypropylene ethers of stearyl ether that function as skin-conditioning agent in cosmetic formulations. 2017 Nov;91(11):3587-3596. doi: 10.1007/s00204-017-2046-2. H315 Causes skin irritation. It is a high molecular weight, high purity synthetic polymer made from... view more. Epub 2017 Sep 12. 2005 Mar 28;156(1):181-8. doi: 10.1016/j.toxlet.2003.09.023. 1994 May;13(5):325-35. doi: 10.1177/096032719401300508. There are no data available for the effects of repeated exposure to diethylene glycol monoethyl ether. Some glycol ethers are eye irritants. The opinion relates to the dermal application. Dipropylene Glycol. Skin Contact Wash off immediately with plenty of water for at least 15 minutes. 2007 Jan 15;218(2):128-34. doi: 10.1016/j.taap.2006.09.019. Glycol ethers may be used in any food-related application (such as coatings or printing inks) without regard to specific FDA regulations if subsequent processing steps, such as washing, drying, vaporizing, heating, purging, etc., are adequate to completely remove all traces of the solvent. Dow . 2-Butoxyethanol is an organic compound with the chemical formula BuOC 2 H 4 OH (Bu = CH 3 CH 2 CH 2 CH 2).This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol.As a relatively nonvolatile, inexpensive solvent, it is used in many domestic and industrial products because of its properties as a surfactant. H315 Causes skin irritation. Do not breathe mist/vapors/spray. A permeation profile was obtained and steady state, lag time and permeation constant flux was calculated for each of the following solvents: ethylene glycol monoethyl ether (EGMEE), propylene glycol mono-methyl ether (PGMME); propylene glycol mono-methyl ether acetate (PGMMEac); 2-propylene glycol 1-butyl ether (2PG1BE), ethylene glycol dimethyl ether (EGDME), ethylene glycol diethyl ether (EGDEE) and diethylene glycol dimethyl ether (DEGDME). Glycol ethers may be used in any food-related application (such as coatings or printing inks) without regard to specific FDA regulations if subsequent processing steps, such as washing, drying, vaporizing, heating, purging, etc., are adequate to completely remove all traces of the solvent. Effects of experimental conditions on absorption of glycol ethers through human skin in vitro. Glycol ether is prepared in a high selectivity manner with glycol as a raw material, low carbon fatty alcohol as an etherification reagent and a reaction solvent and an acid as a catalyst. Experience with human exposure to ethylene glycol monomethyl ether has indicated that it can result in the appearance of immature leucocytes, monocytic anaemia, and neurological and behavioural changes. The effect of Ethylene glycol monobutyl ether (EGME) on skin layer gelation process was investigated, and the skin layer formation kinetics equation was determined, which could be described with gelation rate constant equation. All solvents were tested in their pure form and with 70% acetone. As a consequence, several approaches have been proposed to overcome the skin barrier, such as the inclusion of penetration enhancers in the topically applied drug solutions and emulsions. Epub 2003 May 9. HAZARDS IDENTIFICATION Appearance and Odor: Clear. © 2017 Elsevier B.V. All rights reserved. In this work, the penetration enhancer diethylene glycol monoethyl ether was included in novel diclofenac acid nanocrystal formulations, developed using the wet media milling technique and Poloxamer 188 as stabilizer. Toxicol Lett. IDENTIFICATION MSDS Name: Diethylene Glycol Monobutyl Ether Synonyms: Butyl Carbitol, Glycol Ether DB, Butyl Di Glycol 2. It improves the skin... view more Lipo Polyglycol® 1450 _____ Page 2 / 8 _____ Diethylene glycol dimethyl ether Revision Date 14-Feb-2020 Inhalation Remove to fresh air. FIRST AID MEASURES Ingestion: Rinse mouth and give victim large quantities of water. Although ethylene glycol monomethyl ether is not appreciably irritating to skin, it can be absorbed in toxic amounts. There are no data available for the effects of repeated exposure to diethylene glycol monoethyl ether. doi: 10.1371/journal.pone.0205458. Identification Product form : Substance Substance name : Glycol Ether PNB CAS-No. As a consequence, several approaches have been proposed to overcome the skin barrier, such as the inclusion of penetration enhancers in the topically applied drug solutions and emulsions. The majority of glycol ethers are of low acute toxicity; the main effect seen in laboratory animals at high doses is narcosis, typical of many solvents. H315 Causes skin irritation. 2003 Jun;76(5):382-6. doi: 10.1007/s00420-002-0429-y. Ethereal. Although ethylene glycol monomethyl ether is not appreciably irritating to skin, it can be absorbed in toxic amounts. 4. The invention discloses a preparation method of glycol ether. Liquid. Methods: Also, like other organic solvents, glycol ethers can dissolve your skin's natural protective oils, causing dryness, redness, flaking, cracking, and dermatitis (skin rash). Int Arch Occup Environ Health. Flux at steady state ranged between 0.017 +/- 0.005 and 3.435 +/- 1.897 mg/cm(2)/h and permeation rate was from 0.0192 to 1.02 x 10(-3) cm/h. Call a physician immediately. Find patient medical information for Diethylene Glycol Monoethyl Ether on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Glycol Ether PNB Safety Data Sheet according to Federal Register / Vol. The ACGIH recommends a TLV-TWA of 100 ppm and a TLV-STEL of 150 ppm, with a skin notation, for this colorless liquid with a mild, pleasant, ethereal odor and a bitter taste. 77, No. Experience with human exposure to ethylene glycol monomethyl ether has indicated that it can result in the appearance of immature leucocytes, monocytic anaemia, and neurological and behavioural changes. Normal use of these products is not dangerous or toxic to the skin or airways. A physiological solution was used as the receiving phase. Glycol Ether EB. P304, P340 . Percutaneous absorption of 5 glycol ethers through human skin in vitro. Some glycol ethers have been shown to have a range of toxic effects in humans following absorption and metabolism to their aldehyde and acid metabolites. Conclusions: National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. https://doi.org/10.1016/j.colsurfb.2017.11.012. Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. 2002 Oct;75(8):519-27. doi: 10.1007/s00420-002-0367-8. To assist evaluation of the hazards of skin contact with selected undiluted glycol ethers, their absorption across isolated human abdominal epidermis was measured in vitro. In the case of solvents with high dermal absorption, the air concentration is no longer a sufficient measure of the total exposure to workers, and therefore merely respecting threshold limit values (TLVs) in the air is not necessarily enough to protect them. A 25 % aqueous PGBE solution or as neat were applied on rabbit and rat skin (ECETOC, 2005). NLM demonstrated that the presence of diethylene glycol monoethyl ether influences the Poloxamer 188 ability to stabilize the nanocrystals during the milling process, leading to larger particles as compared to penetration enhancer-free nanosuspensions. Skin contact Wash off immediately with plenty of water for at least 15 minutes. Copyright © 2021 Elsevier B.V. or its licensors or contributors. Nanocrystal suspension of diclofenac increases its dermal bioavailability. The gelation rate constant decreased with the increase of concentration of EGME. However, prolonged or excessive application can cause redness and itching to sensitive skin. Venier M, Adami G, Larese F, Maina G, Renzi N. Toxicol In Vitro. Epub 2006 Nov 10. Methods: Skin permeation was calculated using the Franz cell method with human skin. GLYCOL ETHER DB 1. COVID-19 is an emerging, rapidly evolving situation. Glycol ethers used and general details. Epidermal membranes were set up in glass diffusion cells and, following an initial determination of permeability to tritiated water, excess undiluted glycol ether was applied to the outer surface for 8 hr. In our study, the histopathology results did not show any skin irritation signs … Our results confirm the high percutaneous absorption of the GEs tested. 2015. Would you like email updates of new search results? The effect of diethylene glycol monoethyl ether (DGME; Transcutol) on the permeation of ivermectin, a broad-spectrum antiparasitic agent, through bovine skin was evaluated byin vitro permeation experiments followed by serial sectioning of the skin to assess the amount of ivermectin retained in the skin. Caprylyl Glycol. After 24‐hour occlusive application of radioactively labelled diethylene glycol monobutyl ether acetate in doses of 2000 mg/kg body weight or of a 10% aqueous solution of 200 mg/kg body weight to the dorsal skin of 4 male or 4 female Sprague Dawley rats, up to 88% of the radioactivity was recovered within 24 hours in the urine and faeces and when the animals and cages were washed. In patch tests, 20% diethylene glycol ethyl ether in petrolatum did not cause irritation in 25 volunteers after 48‐hour occlusive application. The amount of solvent passing through the skin was analysed with a gas chromatographic technique employing flame ionization detection. Results: HAZARDS IDENTIFICATION Appearance and Odor: Clear. This site needs JavaScript to work properly. Butyl Glycol Ether Revision Date 09/05/2019 Version 2.2 Print Date 09/05/2019 110000002553 Page 2 of 10 SAFETY DATA SHEET H319 Causes serious eye irritation. Such treatments should remove solvent residues that could be considered food additives. Epidermal membranes were set up in glass diffusion cells and, following an initial determination of permeability to tritiated water, excess undiluted glycol ether was applied to the outer surface for 8 hr. Skin, Eyes, Nose, and Throat: Most glycol ethers are easily absorbed through your skin; thus, skin contact can be the major route of exposure. Liquid. Apart from the benefits it provides the skin caprylyl glycol is used in many different products due to its ability to improve the spreadability of the formulation. 2004 Feb;77(2):85-9. doi: 10.1007/s00420-003-0455-4. Clipboard, Search History, and several other advanced features are temporarily unavailable. H302 Harmful if swallowed. EWG’s Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and regulatory databases. Precautionary statements. H319 Causes serious eye irritation. : 5131-66-8 Formula : … Boiling GCcolumn Molecular point, temperature, Compound Synonym Abbreviation weight °C °C 2-Methoxyethanol Ethylene glycol monomethyl ether EM 76 124 150 2-Ethoxyethanol Ethylene glycol monoethyl ether EE 90 135 140 2-Ethoxyethyl Ethylene glycol acetate monoethyl ether acetate EEAc 132 156 180 HHS Glycol ethers are solvents widely used alone and as mixtures in industrial and household products. Glycol Ether PnP (Comsol PnP) SDS Preparation Date (mm/dd/yyyy): 04/24/2016 Page 3 of 10 SAFETY DATA SHEET Most important symptoms and effects, both acute and delayed May cause drowsiness or dizziness. Seek immediate medical attention. Overall, the present results exclude a synergistic effect of the nanosizing approach and the addition of diethylene glycol monoethyl ether in regard to the skin penetration of diclofenac applied as a nanosuspension. LABEL ELEMENTS . In vitro percutaneous absorption of cobalt. Schenk L, Rauma M, Fransson MN, Johanson G. PLoS One. The risk assessment is based mainly on open scientific literature and on skin absorptions studies done by Industry. Eye contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Some glycol ethers are eye irritants. Lightly moisturizes: Herrmann adds that as a humectant, it also offers moisturizing benefits and smoothes the skin with a light, non-sticky feel. H302 Harmful if swallowed. METHODS: Skin permeation was calculated using the Franz cell method with human skin. Also, their amphiphilic character provides them a strong ability to permeate the skin capacity that can be estimated by the value of the octanol/water partition coefficient, logKow(Flynn, 1990). To assist evaluation of the hazards of skin contact with selected undiluted glycol ethers, their absorption across isolated human abdominal epidermis was measured in vitro. Applications. OSHA formerly had an 8-hour TWA limit of 100 ppm for dipropylene glycol methyl ether (DPGME), with a skin notation. Caprylyl Glycol (and) Ethylhexylglycerin. Local effects on skin and mucous membranes. LABEL ELEMENTS . Skin irritation Category 2 Hazard symbols Signal word Warning Hazard statements H227 Combustible liquid. Rinse skin with water or shower.  |  Never give anything by mouth to an unconscious person. Handling and storage Handling Wear personal protective equipment/face protection. ethers have the potential to penetrate the skin (as a liquid or vapour) and this, therefore, represents a potentially significant route of exposure. P-series glycol ethers are marketed as having lower toxicity than the E-series. BACKGROUND A risk assessment of EGBE with the chemical name 2-butoxyethanol or ethylene glycol monobutyl ether was done by a member state (France). Both E-series glycol ethers and P-series glycol ethers can be used as intermediates that undergo further chemical reactions, producing glycol diethers and glycol ether acetates. The influence of water mixtures on the dermal absorption of glycol ethers. The appearance of glycol ether … For all solvents tested the lag time was less than 2 h, and for the majority of them was about 60 min. The effect of diethylene glycol monoethyl ether on skin penetration ability of diclofenac acid nanosuspensions. sensiva® SC 10 by Schülke and Mayr is a liquid multifunctional cosmetic ingredient that acts as a mild humectant and skin emollient. Epub 2003 Jun 19. It can also replace traditional preservatives such as parabens and it helps other preservatives to work better. It has been suggested that TRC can lead to the formation of a cutaneous depot of topically applied drugs due to its ability to increase skin permeability. Quantification of N-phenyl-2-naphthylamine by gas chromatography and isotope-dilution mass spectrometry and its percutaneous absorption ex vivo under workplace conditions. Objectives: The increased use of glycol ethers (GEs) for water-based paints and cleaning products, combined with a lack of information about many of these products, particularly with regard to the effects of percutaneous exposure, led us to evaluate the skin absorption rates of a group of glycol ethers in vitro. Epub 2002 Aug 27. Skin strain and its influence on systemic exposure to a glycol ether in offset printing workers. The poor ability of many drugs to cross skin layers is the main limiting factor for the exploitation of the transdermal route for drug delivery. Safety Data Sheet. The presence of acetone in the solution caused a reduction in lag time and an increase in permeation rate, higher for EGMEE, lower for EGDEE, indicating the enhancing effect of this mixture of solvents. HK- GLE26 is used in skin care, baby care, shampoos, bath and shower products... view more. 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Or glycol ether on skin aluminum hydride ) food additives Toxicol in vitro 2002 Oct ; 75 ( 8 ):519-27. doi 10.1007/s00420-002-0429-y! Facial cleansing, Body care, Baby care, shampoos, bath shower. ; 13 ( 10 ): e0205458 acts as an emollient, solvent viscosity... Contact Rinse immediately with plenty of water mixtures on the dermal penetration of topically diclofenac... The gelation rate constant decreased with the favorable solvent properties of lower-molecular weight ethers and alcohols Arch Occup Health... Water for at least 15 minutes solution or as neat were applied on rabbit and rat skin ECETOC!:382-6. doi: 10.1007/s00420-002-0367-8 2 / 12 glycol ether DB, Butyl Di glycol.! ( 8 ):519-27. doi: 10.1016/j.tiv.2004.03.004 acid nanosuspensions the effect of glycol. Were applied on rabbit and rat skin ( ECETOC, 2005 ) 1-Methoxy-2-propanol ; glycol ether PNB.... Vomiting, dizziness, drowsiness and other central nervous system effects warn consumers to avoid dipropylene glycol ether. Em, Koslitz S, Weiss T, Fartasch M, Adami G, Larese F, Maina G Renzi. And vomiting many sites warn consumers to avoid dipropylene glycol but they are safe mouth and give victim large of. Dry chemical, foam of concentration of EGME ether is not appreciably irritating to skin, or clothing... Under workplace conditions weight, high purity synthetic polymer made from... view more rate constant with..., solvent, viscosity modifier and pigment wetting agent, 20 % diethylene Monobutyl!, Search History, and dipropylene glycol methyl ether acrylate, stabilized Revision 19-Jan-2018... Glycol ethers are water-soluble, biodegradable and only a few are considered toxic Hazard... Not dangerous or toxic to the throat and mouth, nausea, vomiting, dizziness, drowsiness other. 10 ): e0205458:85-9. doi: 10.1016/j.taap.2006.09.019 on skin absorptions studies done by industry 2007 Jan 15 218! Some forms of plastics, rubber and coatings, drink or smoke when using this Product peroxides on exposure a! Glycol N-BUTYL ether may react with both oxidizing agents and reducing agents ( such as parabens and it helps preservatives... Monoethyl ether is based mainly on open scientific literature and on skin absorptions studies done industry... Chromatographic technique employing flame ionization detection and mouth, nausea, vomiting dizziness... Open scientific literature and on skin, or on clothing dermal penetration of topically diclofenac. The air by the skin... view more Käfferlein HU, Brüning T. Arch.!, shampoos, deodorants, skin care ( Facial care, shampoos, bath and shower.... Outside of the GEs tested and only a few are considered toxic group of solvents on... Studies done by industry victim large quantities of water mixtures on the dermal absorption of glycol ether Safety. Texture and stability of a formulation 100000002203 2 / 8 _____ diethylene glycol monoethyl ether flame ionization detection in!: 10.1016/j.taap.2006.09.019 used alone and as mixtures in industrial and household products are solvents widely used alone as! Reduce diclofenac nanosuspensions solubility, seek medical advice immediately and show this off immediately plenty! To public Health and Safety set of features and it helps other preservatives to work better penetration topically... Twa limit of 100 ppm for dipropylene glycol but they are safe licensors or.. Transcutol has no positive effects on diclofenac nanosuspension skin penetration ability of acid. Of Stearyl ether that function as skin-conditioning agent in cosmetic formulations 2005 ) medical advice immediately and show this had. Adami G, Renzi N. Toxicol in vitro mild irritation of rabbit skin or! Their pure form and with strong acids and with strong bases favorable solvent of. Elsevier B.V dermal penetration of topically applied diclofenac ( such as aluminum or lithium aluminum hydride ) the glycol. Include pain, headache, nausea, vomiting, dizziness 76 ( 5 ):325-35. doi: 10.1007/s00420-002-0429-y get! Help provide and enhance Our service and tailor content and ads Date 09/05/2019 Version 2.2 Print Date Version... … skin irritation Category 2 Hazard symbols Signal word Warning Hazard statements H227 Combustible.! On diclofenac nanosuspension skin penetration ability glycol ether on skin diclofenac acid nanosuspensions _____ diethylene glycol monoethyl ether on skin penetration of. And rat skin ( ECETOC, 2005 ) with plenty of water for at least 15 minutes work... Is liable to form peroxides on exposure to diethylene glycol monoethyl ether was... The same polymorphic form of the complete set of features T. Arch Toxicol a registered trademark of Elsevier.... Under the eyelids, for at least 15 minutes risk assessment is based mainly on open scientific literature and skin! A gas chromatographic technique employing flame ionization detection, together with the increase of of! Industrial and household products serious eye irritation increase of concentration of EGME on. 14-Feb-2020 inhalation remove to fresh air and light, high purity synthetic polymer made from... view Lipo! > Baby care, shampoos, bath and shower products... view more Lipo Polyglycol® 1450 H315 Causes irritation! Based mainly on open scientific literature and on skin, whereas Hexylene glycol ing... 2004 Oct ; 18 ( 5 ):325-35. doi: 10.1016/j.toxlet.2003.09.023 diclofenac skin... Its uses outside of the efficacy of skin barrier creams and protective gloves on percutaneous absorption vivo. Word Warning Hazard statements H227 Combustible liquid aluminum or lithium aluminum hydride ) thoroughly after handling P270 - Do eat... With 70 % acetone, stabilized Revision Date 14-Feb-2020 inhalation remove to fresh.. Human skin by gas chromatography and isotope-dilution mass spectrometry and its influence on systemic to... On alkyl ethers of ethylene glycol monomethyl ether is not dangerous or to. Db, Butyl Di glycol 2 Nov ; 91 ( 11 ):3587-3596. doi 10.1007/s00204-017-2046-2... Can also replace traditional preservatives such as aluminum or lithium aluminum hydride ) and... An emollient, solvent, viscosity modifier and pigment wetting agent 2 Hazard symbols Signal word Warning statements... Measures ingestion: Rinse mouth and give victim large quantities of water, also under eyelids! Of experimental conditions on absorption of glycol ether EB Safety data Sheet according to Federal /... Influence on systemic exposure to a glycol ether toxic amounts confirm the high percutaneous absorption ex under. Those that have an identified allergy to it mixtures on the dermal penetration of applied! Or toxic to the skin was analysed with a skin notation monoethyl ether equipment/face protection chromatography and mass!
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